This study aims to determine the effect of inflation, interest rates and the rupiah exchange rate on the Indonesian Sharia Stock Index (ISSI) for the period 2017 – 2021. This type of research is quantitative research and uses secondary data. The method used in this study uses descriptive statistical analysis, time series regression analysis, classic assumption test using normality test, autocorrelation test, heteroscedasticity test, multicollinearity test, and hypothesis testing using t test, F test and adjusted R squared test. In analyzing this research using the tools of the Eviews12 program. The results of this study partially (t test) on the Indonesian Sharia Stock Index for the period 2017 – 2021 obtained the result that Inflation has a partial effect on the Indonesian Sharia Stock Index. Interest rates have no partial effect on the Indonesian Sharia Stock Index. And the Rupiah Exchange Rate has a partial effect on the Indonesian Sharia Stock Index. Simultaneously (Test F) it is found that Inflation, Interest Rates and Exchange Rates simultaneously affect the Indonesian Sharia Stock Index.